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10 Best Longevity Supplements

BY PUREHEALTH RESEARCH | August 4, 2023

Happy Senior Couple Smiling Outdoors in Nature After Learning About the Best Longevity Supplements

The best longevity supplements contain certain natural substances that have proven “anti-aging” characteristics, improve cellular health, and guard against age-related decline. They aim to supplement the body’s defenses against oxidative stress, cellular damage, and the many variables linked with aging.

“You look much younger than your age”. Even in our late 50s, this is one of the compliments we all hope to hear. Individuals seeking a long and healthy life are increasingly turning to supplements to boost general well-being. Many of the best longevity supplements have gained popularity over recent years due to new research shown to help slow cellular aging.

While no supplement can promise eternal youth, sparking the debate on when to start using anti aging products, several products have acquired popularity due to their notorious health benefits. You cannot prevent aging, but you can slow some aging processes and lower the likelihood of age-related diseases by making dietary and lifestyle adjustments. That’s why we prefer phrases like “healthy aging” rather than “anti-aging”.

The greatest approaches to encourage healthy aging and decrease the detrimental effects of time include:

  • Eating a nutrient-dense diet
  • Exercising regularly
  • Avoiding smoking and excessive alcohol consumption

Individual responses to supplements may vary, so it is best to contact a healthcare practitioner before introducing any new supplements into your daily lifestyle. A nutritious diet, frequent exercise, proper stress management, and other healthy lifestyle behaviors are also crucial in improving longevity and general well-being.

Since the human body is like a machine, over time its parts wear down, taking a toll on functionality as we age, which leads us to seek solutions on how to remove neck wrinkles at home as part of our anti-aging efforts. When this happens, we recommend leaning more on supplements. Longevity supplements include a distinct group of bioactive compounds that target healthy aging at the cellular level. Their target pathway varies, including antioxidant defense, anti-inflammatory properties, and DNA rejuvenation.

Here we’ve compiled a list of the top ten longevity supplements you can consider adding to your diet.

10 Best Longevity Supplements Infographic

1. Resveratrol 

Resveratrol is a naturally occurring chemical present in a variety of plants, most notably the skin of grapes and red wine. It is a polyphenol, which is a type of chemical recognized for its antioxidant qualities.

Because of its tremendous potential in healthy aging, resveratrol has gained popularity. Accumulating studies reveal resveratrol could markedly extend lifespan and health. Its anti-inflammatory, inhibit malignant cell growth, cardioprotective, and neuroprotective effects are well-known. Clinical trials demonstrated its contribution for preserving aging muscle mass, bone density, regulation of mitochondrial function, and autophagy – a process helping remove old damaged cells so healthy new ones can take their place. 

Animal studies, such as those on mice and worms, have demonstrated that resveratrol can increase lifespan and health span (the amount of time spent in excellent health). Nevertheless, its impact on human longevity requires further research. Furthermore, the amount of resveratrol found in natural sources, such as red wine, is relatively modest, making it difficult to consume considerable amounts from food sources alone.

As a result, resveratrol supplements are increasing in popularity. They are often considered one of the best supplements for longevity, but their efficacy and ideal dosages are still pending further research. Before beginning any new program, as with any supplement or natural compound, contact a healthcare provider, especially if you have underlying health concerns or are using drugs that may interact with resveratrol.

2. Coenzyme Q10 (CoQ10)

Coenzyme Q10 (CoQ10) is a naturally existing compound found in all bodily cells. It is essential for energy synthesis within the mitochondria, the cell’s powerhouses. This compound is also an efficient antioxidant that protects cells from oxidative damage. CoQ10 levels naturally decline with age. However, factors like drugs, medical conditions, and lifestyle choices can also decrease their numbers. Supplements containing this compound have become popular due to their possible health advantages.

One of CoQ10’s key activities is its participation in the electron transport chain, a process by which cells convert nutrients into consumable energy in the form of adenosine triphosphate (ATP). This kind of energy is key for the correct functioning of organs and tissues, particularly those with high energy requirements, such as the heart. CoQ10 also has antioxidant capabilities, meaning it aids in the neutralization of harmful free radicals and the reduction of oxidative stress. This oxidative stress contributes to various ailments and the aging process. In addition, CoQ10 assists in regenerating other antioxidants like vitamin E, improving their efficiency.

Several studies have investigated the possible effects of CoQ10 supplementation. So far, this compound has proven to help with cardiovascular health and possibly boost fertility. It may also increase athletic performance and reduce migraine frequency, but further research is necessary to produce definitive evidence for these findings.

3. Curcumin

Curcumin is one of the best longevity supplements and is a naturally occurring chemical found in turmeric, an Indian spice. It is responsible for turmeric’s vivid yellow color and has been part of traditional Ayurvedic treatment for ages. Curcumin has long been the subject of intense research due to its biological and pharmacological properties that combat harmful microbes, and promote healthy aging.

Research shows it possesses formidable antioxidant and anti-inflammatory benefits, inhibits malignant cell growth, and promotes neuroprotective effects. It also supports the liver, kidneys, joints, and gut health. Some research suggests that curcumin may be helpful for various ailments, such as a leaky gut, malignant cell growth, cardiovascular dysfunction, immune-related joint damage, age-related cognitive impairment, and impaired blood sugar metabolism.

Curcumin may also be beneficial to heart health. It could potentially enhance endothelial function (the lining of blood arteries), reduce proinflammatory molecules andLDL cholesterol oxidation (also known as “bad” cholesterol), and improve additional risk factors for heart disease. 

However, it is crucial to remember that curcumin has low bioavailability, meaning the body does not readily absorb it. It is frequently combined with black pepper, which contains piperine that boosts its bioavailability and benefits. 

4. NAD+ Boosters 

NAD+ (nicotinamide adenine dinucleotide) boosters are compounds that help the body produce more NAD+. NAD+ is a coenzyme found in all living cells that is essential for many biological functions, such as energy metabolism, DNA repair, and cellular signaling.

NAD+ levels naturally drop as we age and have been associated with a number of age-related diseases. NAD+ boosters have appeared as a solution for their ability to promote cellular health and possibly slow the aging process. Among the most common NAD+ boosters are:

  • Nicotinamide Mononucleotide (NMN): NMN is a precursor to NAD+ boosters that has attracted attention for its ability to stimulate production of NAD+ and support healthy levels. NMN is also available as a nutritional supplement.
  • Nicotinamide Riboside (NR): NR is a form of vitamin B3 that has been shown in preclinical studies to promote the production of NAD+. Researchers believe it functions in the body by converting into NAD+ and stimulating energy production. NR is available for purchase as a dietary supplement.
  • Fasting: Intermittent fasting or cutting down on calories has been found in animals to boost NAD+ levels and may have a similar impact in humans. Fasting activates a number of cellular processes, such as the activation of sirtuins, which can increase NAD+ levels.

It’s crucial to highlight that while NAD+ boosters show assurance, more research is necessary to properly assess their efficiency, safety, and long-term implications in humans.

5. EGCG

EGCG (Epigallocatechin Gallate) is a form of a plant-based substance known as catechin, which is part of a larger category of plant compounds referred to as polyphenols. It is mainly found in green tea, although nuts and fruits also contain it. It has been the subject of intense scientific research due to its multiple health benefits.

EGCG is a powerful antioxidant that assists in safeguarding cells from free radical damage. It is more potent than vitamins C and E when it comes to antioxidant activity. Numerous disorders are related to chronic inflammation. EGCG also aids in the reduction of overactive immune responses in the body. Research suggests EGCG has excellent anti-mutagenic properties. It has shown promise in suppressing malignant cell development and decreasing the creation of blood vessels that supply them.

Furthermore, EGCG has the potential to prolong longevity and help mitigate age-related disease development. It may also benefit heart health by encouraging healthy cholesterol levels within a normal range, supporting free radical defense against oxidative stress, enhancing blood vessel function, and maintaining healthy systolic-diastolic numbers. All these effects contribute to helping reduce the risk of cardiovascular dysfunction. 

Taking additional EGCG during pregnancy is not advisable as it could disrupt folate metabolism, a B vitamin crucial for fetal growth and development. Taking this compound during pregnancy can also increase the chance of congenital abnormalities such as spina bifida. Individuals with heart disease or liver disease should consult their healthcare professional before taking EGCG.

6. Astaxanthin

Astaxanthin is a naturally occurring pigment belonging to the carotenoid chemical class. It is found in various microalgae as well as some seafood such as salmon, shrimp, and lobster. Astaxanthin is responsible for these organisms’ pink or red color.

Astaxanthin is a unique antioxidant that works inside and outside of cellular membranes to support its integrity and has a high capacity for neutralizing free radicals. Studies have highlighted its numerous biological mechanisms at the cellular level directly linked to longevity-related pathways. Research demonstrates it can slow brain aging by increasing brain-derived neurotrophic factor (BDNF), nicknamed “miracle growth for the brain” by experts.

Astaxanthin preserves skin cells from the detrimental effects of oxidative stress induced by environmental causes such as UV and blue light radiation, pollution, harsh weather conditions, and internal elements such as stress, lack of sleep, and physical exercise.

Clinical research demonstrated that astaxanthin enhanced skin hydration, decreased the occurrence of fine lines and wrinkles, and decreased the appearance and production of age spots. This supplement for longevity promotes younger-looking skin by reducing aging mechanisms. According to research, it may also aid in reducing harmful pro-inflammatory molecules, promoting joint and muscle health, improving skin health, enhancing eye function, and supporting immune system function. 

Additional study is necessary, however, to fully understand the scope of these possible advantages and the ideal dosages for various health issues. While astaxanthin is usually regarded as safe for most people when used in approved quantities, it may interact with certain drugs or cause side effects in some people.

7. L-Glutamine

L-glutamine is a non-essential amino acid required for many physiological functions in the human body. Research suggests that it could be useful in slowing the aging process. It is one of the most prevalent amino acids in the bloodstream and has a role in various metabolic activities. L-glutamine’s participation in protein synthesis is one of its key activities. 

It is a protein building block required for tissue growth and repair, especially in the muscles, intestines, and immune cells. It also helps maintain the body’s nitrogen levels, which is essential for muscle mass maintenance. L-glutamine also favorably affects the immune system. 

It acts as a fuel supply for immune cells such as lymphocytes and macrophages, enhancing their activity and function. This amino acid also helps to keep the intestinal lining healthy by avoiding the breakdown of the gut barrier and boosting gut health.

Athletes and bodybuilders frequently use L-glutamine as a dietary supplement to aid in the recovery of muscles and reduce muscle breakdown during intensive activity. Taking this amino acid could help reduce activity-induced muscle damage and improve exercise performance. Also, L-glutamine has potential advantages in deterring malignant cell growth, alleviating a leaky gut, and inflammatory bowel symptoms, and improving overall health.

8. Astragalus Root

Astragalus root, also known as Astragalus membranaceus or Huang Qi, is a traditional Chinese medicine plant whose use encompasses millennia. It has received lots of praise for its potential health benefits, including immune function, its ability to slow the aging process, and overall well-being. The medicinal properties of astragalus root come from polysaccharides, antioxidant flavonoids and saponins and two powerful unique compounds called cycloastragenol, and astragaloside IV. 

Recent human and animal studies show the unique compounds dramatically lengthen telomeres of DNA by 430% – the yardstick of cellular aging. That means the longer your cells remain younger, the better they perform. Researchers found that components astragaloside IV improved markers of the cardiovascular, immune, digestive, and nervous systems. It helped regulate calcium balance, support free radical defense, protect against cell death, combat harmful pathogens, and more. 

It benefits the heart, lungs, and blood. Astragalus reduces symptoms of hay fever, fatigue, swelling, and improves skin health. It also supports healthy blood sugar and kidney functions.

Astragalus is also frequently used as an adaptogen, which is a substance that assists the body in adapting to stress and maintaining balance.

One of the key functions of the astragalus root is to support immunological function. It has the power to activate and boost the activity of specific immune cells, such as T-cells and natural killer cells, which are important in the body’s defense against diseases and foreign invaders. Astragalus also has antioxidant capabilities and may assist in protecting cells from free radical damage.

Astragalus root is accessible in numerous forms, including capsules, powders, and teas. It is generally regarded as safe for most people when taken appropriately. 

9. L-Ornithine Alpha-Ketoglutarate

L-ornithine OKG (Alpha-Ketoglutarate) is a chemical made up of two molecules: L-ornithine and alpha-ketoglutarate. L-ornithine is a non-essential amino acid that the body can synthesize, whereas alpha-ketoglutarate is an intermediary in the citric acid cycle, which is essential in energy metabolism.

OKG is also a precursor for producing essential amino acids that aid in protein production, such as glutamine, arginine, and proline. It supports healthy immunological function and promotes the secretion of hormones for glucose and human growth hormone (HGH). HGH is critical for new cell and tissue regeneration. OKG helps modulate proteins for retaining muscle mass during aging. In addition, it significantly decreases cortisol/DHEA-S hormones, reducing stress and improving sleep quality.

A recent mouse study at the Buck Institute, one of the world’s leading aging research organizations, discovered that alpha-ketoglutarate increased the lifetime of aged mice by 12%. Interestingly, alpha-ketoglutarate increased the health span by 41%. The mice lived longer and remained healthier and disease-free for far more time. 

However, it is crucial to highlight that the scientific data supporting the specific benefits of OKG is limited, and more study is required. Before taking OKG, as with any dietary supplement, contact a healthcare practitioner, especially if you have any underlying medical conditions or are taking drugs. They can give you specialized counsel based on your specific health needs.

10. L-Lysine HCL

Lysine hydrochloride, or HCL, is a common form of the important amino acid L-lysine. It is an essential nutrient required for many physiological functions in the human body. Lysine is a vital amino acid, meaning the body cannot synthesize it, and you need to acquire it through diet or supplements. It is present in high-protein meals, including meat, fish, eggs, and beans. Lysine has a vital role in the creation of proteins, enzymes, and hormones, as well as in calcium absorption.

Lysine is an essential building block crucial for keeping healthy skin, connective tissues, joint cartilage, tendons, and bones since it takes part in collagen synthesis and combats pathogens. It also promotes HGH production vital to rejuvenate your body by stimulating new cell growth and regeneration. That means it boosts collagen and elastin, reducing fine lines, wrinkles and commanding a healthier, youthful, glowing complexion. L-lysine HCL is widely accessible as a nutritional supplement for longevity in tablet, capsule, or powder form.

Turn on Your Youth Switch 

Youth Switch is a revolutionary product designed to help you turn on your youth switch and unlock the potential for a vibrant and healthy life. With its potent blend of supplements, like L-glutamine, Astragalus root, L-ornithine alpha-ketoglutarate, and L-lysine HCL, Youth Switch offers a comprehensive approach to longevity and overall well-being. At the heart of Youth Switch is the expertise of Dr. Holly Lucille, ND, a renowned naturopathic doctor who has dedicated her career to promoting optimal health vitality.

Youth Switch product by PureHealth Research

PureHealth Research health experts and scientists strategically formulated synergistic powerhouses in this superior quality “next generation” nutraceutical to support longevity and combat the effects of aging. L-glutamine targets cellular health, supporting the body’s natural regenerative processes, nourishing and defending cell integrity, and promoting longevity and overall vitality. This supplement also supports healthy cognitive function, memory, focus, mental clarity, and brain aging. 

L-ornithine alpha-ketoglutarate supports heart health, which is crucial for longevity. Finally, L-lysine HCL promotes joint health, flexibility, and range of motion, allowing you to stay active and mobile as you age. Other supplements in this product also play a significant role in maintaining organ and metabolic health, blood flow, sleep quality, gut health, positive mood, stress management, immune functions, and overall well-being. Recognizing the best vitamins for men over 40 is a key aspect of this product’s design, ensuring that it addresses the specific nutritional needs of this demographic.

It is always advisable to consult with a healthcare professional, such as Dr. Holly Lucille, ND, who can provide personalized guidance and recommendations based on individual needs.

Final Thoughts 

In conclusion, these best longevity supplements show promise as potential aids in improving your general well-being and extending your lifespan. While research into the particular benefits of these supplements is ongoing, preliminary findings indicate that they may have positive features which may lead to increased longevity.

However, these vitamins for longevity must be approached with caution because their safety and effectiveness might differ based on individual circumstances. Before introducing longevity supplements into one’s regimen, it is best to check with a healthcare practitioner and prioritize a balanced diet, frequent exercise, and other lifestyle aspects known to improve overall health and longevity.


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